Article
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.
Nature - 5 Jul 2007
Chow Clement Y, Zhang Yanling, Dowling James J, Jin Natsuko, Adamska Maja, Shiga Kensuke, Szigeti Kinga, Shy Michael E, Li Jun, Zhang Xuebao, Lupski James R, Weisman Lois S, Meisler Miriam H
Abstract excerpt
Membrane-bound phosphoinositides are signalling molecules that have a key role in vesicle trafficking in eukaryotic cells. Proteins that bind specific phosphoinositides mediate interactions between membrane-bounded compartments whose identity is partially encoded by cytoplasmic phospholipid tags. Little is known about the localization and regulation of mammalian phosphatidylinositol-3,5-bisphosphate...
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