Article
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND).
Diabetes - 1 Jan 2008
Schelling Jeffrey R, Abboud Hanna E, Nicholas Susanne B, Pahl Madeleine V, Sedor John R, Adler Sharon G, Arar Nedal H, Bowden Donald W, Elston Robert C, Freedman Barry I, Goddard Katrina A B, Guo Xiuqing, Hanson Robert L, Ipp Eli, Iyengar Sudha K, Jun Gyungah, Kao W H Linda, Kasinath Balakuntalam S, Kimmel Paul L, Klag Michael J, Knowler William C, Nelson Robert G, Parekh Rulan S, Quade Shannon R, Rich Stephen S, Saad Mohammed F, Scavini Marina, Smith Michael W, Taylor Kent, Winkler Cheryl A, Zager Philip G, Shah Vallabh O
Abstract excerpt
OBJECTIVE: Diabetic nephropathy, the most common cause of end-stage renal disease, aggregates in families and specific ethnic groups. Deconstructing diabetic nephropathy into intermediate, quantitative phenotypes may increase feasibility of detecting susceptibility loci by genetic screens. Glomerular filtration rate (GFR), which characterizes diabetic nephropathy, was employed as a quantitative trait in a...
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