Article
DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.
Human molecular genetics - 1 May 2014
Perry John R B, Hsu Yi-Hsiang, Chasman Daniel I, Johnson Andrew D, Elks Cathy, Albrecht Eva, Andrulis Irene L, Beesley Jonathan, Berenson Gerald S, Bergmann Sven, Bojesen Stig E, Bolla Manjeet K, Brown Judith, Buring Julie E, Campbell Harry, Chang-Claude Jenny, Chenevix-Trench Georgia, Corre Tanguy, Couch Fergus J, Cox Angela, Czene Kamila, D'adamo Adamo Pio, Davies Gail, Deary Ian J, Dennis Joe, Easton Douglas F, Engelhardt Ellen G, Eriksson Johan G, Esko Tõnu, Fasching Peter A, Figueroa Jonine D, Flyger Henrik, Fraser Abigail, Garcia-Closas Montse, Gasparini Paolo, Gieger Christian, Giles Graham, Guenel Pascal, Hägg Sara, Hall Per, Hayward Caroline, Hopper John, Ingelsson Erik, Kardia Sharon L R, Kasiman Katherine, Knight Julia A, Lahti Jari, Lawlor Debbie A, Magnusson Patrik K E, Margolin Sara, Marsh Julie A, Metspalu Andres, Olson Janet E, Pennell Craig E, Polasek Ozren, Rahman Iffat, Ridker Paul M, Robino Antonietta, Rudan Igor, Rudolph Anja, Salumets Andres, Schmidt Marjanka K, Schoemaker Minouk J, Smith Erin N, Smith Jennifer A, Southey Melissa, Stöckl Doris, Swerdlow Anthony J, Thompson Deborah J, Truong Therese, Ulivi Sheila, Waldenberger Melanie, Wang Qin, Wild Sarah, Wilson James F, Wright Alan F, Zgaga Lina, Ong Ken K, Murabito Joanne M, Karasik David, Murray Anna
Abstract excerpt
The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain...
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