Article
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.
Gastroenterology - 1 Feb 2018
Biczo Gyorgy, Vegh Eszter T, Shalbueva Natalia, Mareninova Olga A, Elperin Jason, Lotshaw Ethan, Gretler Sophie, Lugea Aurelia, Malla Sudarshan R, Dawson David, Ruchala Piotr, Whitelegge Julian, French Samuel W, Wen Li, Husain Sohail Z, Gorelick Fred S, Hegyi Peter, Rakonczay Zoltan, Gukovsky Ilya, Gukovskaya Anna S
Abstract excerpt
BACKGROUND & AIMS: Little is known about the signaling pathways that initiate and promote acute pancreatitis (AP). The pathogenesis of AP has been associated with abnormal increases in cytosolic Ca2+, mitochondrial dysfunction, impaired autophagy, and endoplasmic reticulum (ER) stress. We analyzed the mechanisms of these dysfunctions and their relationships, and how these contribute to development of AP in mice...
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