Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.

Oncogene - 27 Aug 2009

Haan S, Wüller S, Kaczor J, Rolvering C, Nöcker T, Behrmann I, Haan C

Abstract excerpt

Recently, mutations in the gene of Janus kinase 2 (Jak2) were discovered in patients suffering from chronic myeloproliferative disorders (MPD) and leukemia. As suppressors of cytokine signaling (SOCS) proteins are potent feedback inhibitors of Jak-mediated signaling, we investigated their role in signal transduction through constitutively active Jak2 mutants. We selected two mutants, Jak2-V617F and Jak2-K539L,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Janus Kinase 2
Share to Proteasome Endopeptidase Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Transport

Share to STAT5 Transcription Factor

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Suppressor of Cytokine Signaling 3 Protein

Share to Suppressor of Cytokine Signaling Proteins

Source

Identifiers

PMID: 19543316
DOI: 10.1038/onc.2009.155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.PMID 19543316Read ↗

SOCS2: physiological and pathological functions.Semantic proximity Read ↗

SOCS2 physiological and pathological functionsSemantic proximity Read ↗

The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3.Semantic proximity Read ↗

JAK/STAT signal transduction: regulators and implication in hematological malignancies.Semantic proximity Read ↗

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.Semantic proximity Read ↗

JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition.Semantic proximity Read ↗

SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases.Semantic proximity Read ↗

SOCS: suppressors of cytokine signalling.Semantic proximity Read ↗

JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional ConsequencesSemantic proximity Read ↗

JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.Semantic proximity Read ↗

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell functionSemantic proximity Read ↗

An Unusual Insertion in Jak2 Is Crucial for Kinase Activity and Differentially Affects Cytokine ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.