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Article

Development of a Luminex-based multiplex assay for detection of mutations conferring resistance to Echinocandins in Candida glabrata.

Journal of clinical microbiology - 1 Mar 2014

Pham Cau D, Bolden Carol B, Kuykendall Randall J, Lockhart Shawn R

Abstract excerpt

Echinocandins are the recommended treatment for invasive candidiasis due to Candida glabrata. Resistance to echinocandins is known to be caused by nonsynonymous mutations in the hot spot-1 (HS1) regions of the FKS1 and FKS2 genes, which encode a subunit of the β-1,3-glucan synthase, the target of echinocandins. Here, we describe the development of a microsphere-based assay using Luminex MagPix technology to...

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Identifiers

PMID: 24353003
DOI: 10.1128/JCM.03378-13
PMCID: PMC3957770

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