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Article

Dispersed and conserved hydrophobic residues of HIV-1 Vif are essential for CBFβ recruitment and A3G suppression.

Journal of virology - 1 Mar 2014

Zhou Xiaohong, Han Xue, Zhao Ke, Du Juan, Evans Sean L, Wang Hong, Li Peng, Zheng Wenwen, Rui Yajuan, Kang Jian, Yu Xiao-Fang

Abstract excerpt

UNLABELLED: CBFβ was recently found to be a key regulator of the ability of human immunodeficiency virus type 1 (HIV-1) Vif to overcome host antiviral APOBEC3 proteins. However, the detailed molecular requirements for the Vif-CBFβ interaction are still not clear. Here, we mapped the minimum Vif domain required for CBFβ binding. In terms of CBFβ binding, the Vif N terminus was very sensitive to deletions. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vif Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 24352440
DOI: 10.1128/JVI.03604-13
PMCID: PMC3958093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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