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Identification of 81 LGxGxxIxW 89 and 171 EDRW 174 Domains from Human Immunodeficiency Virus Type 1 Vif That Regulate APOBEC3G and APOBEC3F Neutralizing Activity

25 Mar 2010

Abstract excerpt

The human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) potently restrict human immunodeficiency virus type 1 (HIV-1) replication, but they are neutralized by the viral protein Vif. Vif bridges A3G and A3F with a Cullin 5 (Cul5)-based E3 ubiquitin ligase and mediates their proteasomal degradation. This mechanism has been extensively studied, and several Vif domains have been identified that are critical...

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PMID: 20335268
DOI: 10.1128/jvi.00079-10

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Identification of 81 LGxGxxIxW 89 and 171 EDRW 174 Domains from Human Immunodeficiency Virus Type 1 Vif That Regulate APOBEC3G and APOBEC3F Neutralizing ActivityPMID 20335268Read ↗

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