Article
Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction.
Journal of molecular biology - 12 Sept 2008
He Zhiwen, Zhang Wenyan, Chen Gongying, Xu Rongzhen, Yu Xiao-Fang
Abstract excerpt
Apolipoprotein B mRNA-editing catalytic polypeptide-like 3G (APOBEC3G, or A3G) and related cytidine deaminases such as apolipoprotein B mRNA-editing catalytic polypeptide-like 3F (APOBEC3F, or A3F) are potent inhibitors of retroviruses. Formation of infectious human immunodeficiency virus (HIV)-1 requires suppression of multiple cytidine deaminases by Vif. HIV-1 Vif suppresses various APOBEC3 proteins through a...
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