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Article

Fuchs Endothelial Corneal Dystrophy: Strong Association with rs613872 Not Paralleled by Changes in Corneal Endothelial TCF4 mRNA Level.

BioMed research international - 1 Jan 2015

Ołdak Monika, Ruszkowska Ewelina, Udziela Monika, Oziębło Dominika, Bińczyk Ewelina, Ścieżyńska Aneta, Płoski Rafał, Szaflik Jacek P

Abstract excerpt

Fuchs endothelial corneal dystrophy (FECD) is a common corneal endotheliopathy with a complex and heterogeneous genetic background. Different variants in the TCF4 gene have been strongly associated with the development of FECD. TCF4 encodes the E2-2 transcription factor but the link between the strong susceptibility locus and disease mechanism remains elusive. Here, we confirm a strong positive association...

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Identifiers

PMID: 26451375
DOI: 10.1155/2015/640234
PMCID: PMC4588027

Genes

TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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