Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.

doi:10.1089/ten.TEC.2014.0698

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Article

Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.

Tissue engineering. Part C, Methods - 1 Sept 2015

Berning Manuel, Prätzel-Wunder Silke, Bickenbach Jackie R, Boukamp Petra

Abstract excerpt

Three-dimensional in vitro skin and skin cancer models help to dissect epidermal-dermal and tumor-stroma interactions. In the model presented here, normal human dermal fibroblasts isolated from adult skin self-assembled into dermal equivalents with their specific fibroblast-derived matrix (fdmDE) over 4 weeks. The fdmDE represented a complex human extracellular matrix that was stabilized by its own heterogeneous...

Topics

Cell Count
Dermis
Disease Progression
Epidermal Cells
Epithelium
Extracellular Matrix
Fibroblasts
Humans
Imaging, Three-Dimensional
Keratinocytes
Matrix Metalloproteinases
Models, Biological
Neoplasms, Squamous Cell
Phenotype
Skin
Skin Neoplasms
Skin, Artificial

Source

Open in PubMed

Identifiers

PMID: 25837604
DOI: 10.1089/ten.TEC.2014.0698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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