Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Slow carbamazepine clearance in a nonadherent Malay woman with epilepsy and thyrotoxicosis.

Therapeutic drug monitoring - 1 Feb 2014

Yeap Li-Ling, Lim Kheng-Seang, Ng Ching-Ching, Hui-Ping Khor Amy, Lo Yoke-Lin

Abstract excerpt

The authors describe a case of a 37-year-old Malay lady with an unusually slow carbamazepine clearance, which may be related to genetic polymorphisms of drug metabolizing enzymes and transporters. When given a small daily dose of 200 mg immediate-release carbamazepine, this patient experienced drowsiness. Subsequently, she reduced her carbamazepine dose to 200 mg twice a week (on Mondays and Fridays), resulting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Carbamazepine
Share to Drug Monitoring

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperthyroidism

Share to Malaysia

Share to Medication Adherence

Share to Multidrug Resistance-Associated Protein 2

Share to Propranolol

Source

Identifiers

PMID: 24342894
DOI: 10.1097/FTD.0000000000000024

Genes

ABCB1
ABCC2
EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slow carbamazepine clearance in a nonadherent Malay woman with epilepsy and thyrotoxicosis.PMID 24342894Read ↗

Review or Updates on the clinical pharmacokinetics of levetiracetamSemantic proximity Read ↗

Genetic polymorphisms of microsomal epoxide hydrolase and UDP-glucuronosyltransferase (UGT) and its effects on plasma carbamazepine levels and metabolic ratio in persons with epilepsy of South India: A cross-sectional genetic association study.Semantic proximity Read ↗

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological DiseasesSemantic proximity Read ↗

Multidrug Resistance-1 C3435T Polymorphism and Carbamazepine Plasma Level in Indonesian Temporal Lobe Epilepsy Patients.Semantic proximity Read ↗

CYP1A2 genotype affects carbamazepine pharmacokinetics in children with epilepsy.Semantic proximity Read ↗

Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on dose-adjusted plasma levels of carbamazepine in epileptic patients in South Indian population.Semantic proximity Read ↗

Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.Semantic proximity Read ↗

Severe carbamazepine-induced drug reaction and whole genome analysis: case reportSemantic proximity Read ↗

Pharmacokinetic Changes and Seizure Outcomes in Pregnant Women Taking Second-Generation Antiepileptic DrugsSemantic proximity Read ↗

Association of ABCB1 polymorphisms with carbamazepine metabolism and resistance in epilepsy: A meta-analysis.Semantic proximity Read ↗

Population pharmacokinetics of oxcarbazepine active metabolite in Chinese children with epilepsy.Semantic proximity Read ↗

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.