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Article

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.

Pharmacogenomics - 1 Jan 2013

Puranik Yogita Ghodke, Birnbaum Angela K, Marino Susan E, Ahmed Ghada, Cloyd James C, Remmel Rory P, Leppik Ilo E, Lamba Jatinder K

Abstract excerpt

AIM: The aim of this study was to evaluate the association of genetic variants in the major genes involved in carbamazepine (CBZ) metabolism and transport with its pharmacokinetics in epilepsy patients. MATERIALS & METHODS: Twenty-five SNPs within seven CBZ pathway genes, namely CYP3A4, CYP3A5, EPHX1, NR1I2, UGT2B7, ABCB1 and ABCC2, were analyzed for association with CBZ pharmacokinetics in 90 epilepsy patients....

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Source

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Identifiers

PMID: 23252947
DOI: 10.2217/pgs.12.180
PMCID: PMC3570048

Genes

ABCB1
ABCC2
EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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