Article
Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations.
Genetics and molecular research : GMR - 26 Nov 2013
Wang L S, Jiao Y, Huang Y, Liu X Y, Gibson G, Bennett B, Hamre K M, Li D W, Zhao H Y, Gelernter J, Kranzler H R, Farrer L A, Lu L, Wang Y J, Gu W K
Abstract excerpt
In prior work, congenic strains carrying the DBA/2Igb (D2) region of chromosome 2 (Chr2) for alcohol preference were bred onto a C57BL/6Ibg (B6) background and as predicted were found to reduce voluntary consumption. Subsequently, interval-specific congenic recombinant strains (ISCRS) were generated and also tested. These ISCRS strains reduced the quantitative trait loci (QTL) interval to a comparatively small...
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