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Article

Role of the Apt1 protein in polysaccharide secretion by Cryptococcus neoformans.

Eukaryotic cell - 1 Jun 2014

Rizzo Juliana, Oliveira Débora L, Joffe Luna S, Hu Guanggan, Gazos-Lopes Felipe, Fonseca Fernanda L, Almeida Igor C, Frases Susana, Kronstad James W, Rodrigues Marcio L

Abstract excerpt

Flippases are key regulators of membrane asymmetry and secretory mechanisms. Vesicular polysaccharide secretion is essential for the pathogenic mechanisms of Cryptococcus neoformans. On the basis of the observations that flippases are required for polysaccharide secretion in plants and the putative Apt1 flippase is required for cryptococcal virulence, we analyzed the role of this enzyme in polysaccharide release...

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Identifiers

PMID: 24337112
DOI: 10.1128/EC.00273-13
PMCID: PMC4054279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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