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Article

Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS

13 Jun 2013

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) presents clinically in adulthood and is characterized by the loss of motoneurons in the spinal cord and cerebral cortex. Animal models of the disease suggest that significant neuronal abnormalities exist during preclinical stages of the disease. Mutations in the gene fused in sarcoma (FUS) are associated with ALS and cause impairment in motor function in animal models. However,...

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PMID: 23771027
DOI: 10.1093/hmg/ddt278

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