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p16 INK4A is a robust in vivo biomarker of cellular aging in human skin

15 Aug 2006

Abstract excerpt

The cell-cycle regulating gene, p16INK4A, encoding an inhibitor of cyclin-dependent kinases 4 and 6, is considered to play an important role in cellular aging and in premature senescence. Although there is an age-dependent increase of p16INK4A expression in human fibroblast senescence in vitro, no data are available regarding the age dependency of p16INK4A in vivo. To determine whether p16INK4A expression in...

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PMID: 16911562
DOI: 10.1111/j.1474-9726.2006.00231.x

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