Article
Type 1 diabetes-associated TLR responsiveness of oral epithelial cells.
Journal of dental research - 1 Feb 2014
Neiva K G, Calderon N L, Alonso T R, Panagakos F, Wallet S M
Abstract excerpt
In type 1 diabetes (T1D), a Toll-like receptor (TLR)-hyper-inflammatory monocytic phenotype has been implicated as a mechanism of exacerbated tissue destruction. Other cells of the periodontium, including oral epithelial cells (OECs), express innate immune receptors, including TLRs. To delineate the TLR responses of OECs derived from T1D participants and to determine effects of the anti-inflammatory agent...
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