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Article

Maternal-fetal metabolic gene-gene interactions and risk of neural tube defects.

Molecular genetics and metabolism - 1 Jan 2014

Lupo Philip J, Mitchell Laura E, Canfield Mark A, Shaw Gary M, Olshan Andrew F, Finnell Richard H, Zhu Huiping

Abstract excerpt

Single-gene analyses indicate that maternal genes associated with metabolic conditions (e.g., obesity) may influence the risk of neural tube defects (NTDs). However, to our knowledge, there have been no assessments of maternal-fetal metabolic gene-gene interactions and NTDs. We investigated 23 single nucleotide polymorphisms among 7 maternal metabolic genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, and TCF7L2)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24332798
DOI: 10.1016/j.ymgme.2013.11.004
PMCID: PMC4394735

Genes

ENPP1
SLC2A2
ADRB3
FTO
LEP
PPARG
PPARGC1A
TCF7L2
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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