Article
The aquaporin 1 C-terminal tail is required for migration and growth of pulmonary arterial myocytes.
American journal of respiratory cell and molecular biology - 1 Jun 2014
Lai Ning, Lade Julie, Leggett Kyle, Yun Xin, Baksh Syeda, Chau Eric, Crow Michael T, Sidhaye Venkataramana, Wang Jian, Shimoda Larissa A
Abstract excerpt
Pulmonary arterial smooth muscle cell (PASMC) proliferation and migration are important contributors to the vascular remodeling that occurs during development of pulmonary hypertension. We previously demonstrated that aquaporin (AQP)1, a member of the water channel family of proteins, was expressed in PASMCs and was necessary for hypoxia-induced migration; however, the mechanism by which AQP1 controls this...
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