Article
Pulmonary artery endothelial cell phenotypic alterations in a large animal model of pulmonary arteriovenous malformations after the Glenn shunt.
The Annals of thoracic surgery - 1 Oct 2013
Kavarana Minoo N, Mukherjee Rupak, Eckhouse Shaina R, Rawls William F, Logdon Christina, Stroud Robert E, Patel Risha K, Nadeau Elizabeth K, Spinale Francis G, Graham Eric M, Forbus Geoffrey A, Bradley Scott M, Ikonomidis John S, Jones Jeffrey A
Abstract excerpt
BACKGROUND: Longevity of the superior cavopulmonary connection (SCPC) is limited by the development of pulmonary arteriovenous malformations (PAVM). The goal of this study was to determine whether phenotypic changes in pulmonary artery endothelial cells (PAEC) that favor angiogenesis occur with PAVM formation. METHODS: A superior vena cava to right pulmonary artery connection was constructed in 5 pigs. Pulmonary...
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