Article
A functional polymorphism in MIR196A2 is associated with risk and progression of nasopharyngeal carcinoma in the Chinese population.
Genetic testing and molecular biomarkers - 1 Mar 2014
Li Peiyao, Yan Hongbo, Zhang Hongxing, Yu Lixia, Wang Zhifu, Zhai Yun, Xia Xia, Zhang Jiye, Zhang Yang, Ma Fuchao, Huang Wenfeng, Cai Mi, Cui Ying, He Fuchu, Zhou Gangqiao
Abstract excerpt
BACKGROUND: Genetic variations in microRNAs may alter their processing, expression, and binding to target mRNAs, consequently affecting many cancer-related biological processes. Recently, a polymorphism rs11614913 in MIR196A2 was shown to affect the processing of the precursor microRNA into its mature forms and the repertoire of target mRNAs with which it interacts. We examined whether this polymorphism was...
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