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Article

LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction.

G3 (Bethesda, Md.) - 31 Jul 2018

Sorkaç Altar, DiIorio Michael A, O'Hern Patrick J, Baskoylu Saba N, Graham Hannah K, Hart Anne C

Abstract excerpt

The role of Notch signaling in cell-fate decisions has been studied extensively; however, this pathway is also active in adult tissues, including the nervous system. Notch signaling modulates a wide range of behaviors and processes of the nervous system in the nematode Caenorhabditis elegans, but there is no evidence for Notch signaling directly altering synaptic strength. Here, we demonstrate Notch-mediated...

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PMID: 29950427
DOI: 10.1534/g3.118.200202
PMCID: PMC6071610

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