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Article

Influence of BCL2 gene in major depression susceptibility and antidepressant treatment outcome.

Journal of affective disorders - 1 Feb 2014

Zhang Chen, Wu Zhiguo, Hong Wu, Wang Zuowei, Peng Daihui, Chen Jun, Yuan Chengmei, Yu Shunying, Xu Lin, Fang Yiru

Abstract excerpt

BACKGROUND: Our recent work indicated that low-expression of the anti-apoptotic protein B-cell/lymphoma 2 (Bcl-2) mRNA was observed among untreated major depressive disorder (MDD) patients, and the subsequent altered level of Bcl-2 was found to be close to the antidepressant treatment outcome. The primary aim of this present study was to examine whether a particular gene, encoding Bcl-2 (BCL2) confers risk to...

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Source

Identifiers

PMID: 24321200
DOI: 10.1016/j.jad.2013.11.010

Genes

BCL2
TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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