Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression.

Journal of affective disorders - 1 Oct 2015

Santos Marlene, Carvalho Serafim, Lima Luís, Mota-Pereira Jorge, Pimentel Paulo, Maia Dulce, Correia Diana, Gomes Sofia, Cruz Agostinho, Medeiros Rui

Abstract excerpt

BACKGROUND: Hippocampal neurogenesis has been suggested as a downstream event of antidepressants (AD) mechanism of action and might explain the lag time between AD administration and the therapeutic effect. Despite the widespread use of AD in the context of Major Depressive Disorder (MDD) there are no reliable biomarkers of treatment response phenotypes, and a significant proportion of patients display Treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fas Ligand Protein

Share to fas Receptor

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 26186532
DOI: 10.1016/j.jad.2015.06.027

Genes

FAS
TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression.PMID 26186532Read ↗

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.Semantic proximity Read ↗

Understanding the genetic aspects of resistance to antidepressants treatment.Semantic proximity Read ↗

Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample.Semantic proximity Read ↗

From Immune Activation to Cell Death: Investigating the Pro-inflammatory Phenotype of PBMCs in Major Depressive DisorderSemantic proximity Read ↗

Treatment-resistant depression: molecular mechanisms and managementSemantic proximity Read ↗

Beyond the resistance: how novel neurobiological understandings of depression may lead to advanced treatment strategies.Semantic proximity Read ↗

A Genetic Profile of Refractory Individuals with Major Depressive Disorder and Their Responsiveness to Transcranial Magnetic StimulationSemantic proximity Read ↗

Suicidal ideation during antidepressant treatment: do genetic predictors exist?Semantic proximity Read ↗

Kinase gene haplotypes and gene-gene interactions in the Ras-Raf-MAPK signaling pathway: association with antidepressant remission.Semantic proximity Read ↗

Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.Semantic proximity Read ↗

Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acidsSemantic proximity Read ↗

The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.