Article
Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Apr 2016
Shen Fangyuan, Chen Jiejun, Guo Shicheng, Zhou Yinghui, Zheng Yabiao, Yang Yajun, Zhang Junjie, Wang Xiaofeng, Wang Chenji, Zhao Dunmei, Wang Mengyun, Zhu Meiling, Fan Lixia, Xiang Jiaqing, Xia Yong, Wei Qingyi, Jin Li, Wang Jiucun, Wang Minghua
Abstract excerpt
Esophageal squamous cell carcinoma (ESCC) is the dominant type of esophageal cancer in the East Asian population. MicroRNAs (miRNAs) have been studied to play important roles in tumorigenesis. Single nucleotide polymorphisms (SNPs) in miRNA lead to the aberrant expression and structural alteration of miRNA and are hypothesized to be involved in tumorigenesis and cancer development. We conducted a population-based...
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