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Article

Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.

Nucleic acids research - 1 Feb 2014

Baharoglu Zeynep, Babosan Anamaria, Mazel Didier

Abstract excerpt

Sub-inhibitory concentrations (sub-MIC) of antibiotics play a very important role in selection and development of resistances. Unlike Escherichia coli, Vibrio cholerae induces its SOS response in presence of sub-MIC aminoglycosides. A role for oxidized guanine residues was observed, but the mechanisms of this induction remained unclear. To select for V. cholerae mutants that do not induce low...

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PMID: 24319148
DOI: 10.1093/nar/gkt1259
PMCID: PMC3936754

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