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Article

Evidence for Paternal Age-Related Alterations in Meiotic Chromosome Dynamics in the Mouse

7 Dec 2013

Abstract excerpt

Increasing age in a woman is a well-documented risk factor for meiotic errors, but the effect of paternal age is less clear. Although it is generally agreed that spermatogenesis declines with age, the mechanisms that account for this remain unclear. Because meiosis involves a complex and tightly regulated series of processes that include DNA replication, DNA repair, and cell cycle regulation, we postulated that...

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PMID: 24318536
DOI: 10.1534/genetics.113.158782

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