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Article

Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.

Journal of the National Cancer Institute - 1 Jan 2014

Yamamoto Hiromasa, Higasa Koichiro, Sakaguchi Masakiyo, Shien Kazuhiko, Soh Junichi, Ichimura Koichi, Furukawa Masashi, Hashida Shinsuke, Tsukuda Kazunori, Takigawa Nagio, Matsuo Keitaro, Kiura Katsuyuki, Miyoshi Shinichiro, Matsuda Fumihiko, Toyooka Shinichi

Abstract excerpt

We encountered a family of Japanese descent in which multiple members developed lung cancer. Using whole-exome sequencing, we identified a novel germline mutation in the transmembrane domain of the human epidermal growth factor receptor 2 (HER2) gene (G660D). A novel somatic mutation (V659E) was...

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Identifiers

PMID: 24317180
DOI: 10.1093/jnci/djt338
PMCID: PMC3906987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24317180-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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