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Article

CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.

Nature reviews. Cancer - 1 Oct 2014

Ramdzan Zubaidah M, Nepveu Alain

Abstract excerpt

CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and progression. The accumulated evidence supports a model of haploinsufficiency whereby reduced CUX1 expression promotes tumour development. Paradoxically, increased CUX1 expression is associated with tum...

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Source

Identifiers

PMID: 25190083
DOI: 10.1038/nrc3805

Genes

CUX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25190083-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.PMID 25190083Read ↗

Inactivating CUX1 mutations promote tumorigenesis.Semantic proximity Read ↗

RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA DamageSemantic proximity Read ↗

The multiple roles of CUX1: insights from mouse models and cell-based assays.Semantic proximity Read ↗

Distinct clinical and biological implications of CUX1 in myeloid neoplasmsSemantic proximity Read ↗

Elevated YBX1 mRNA expression is associated with a genomically unstable and clinically aggressive cancer state: a pan-cancer analysisSemantic proximity Read ↗

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.Semantic proximity Read ↗

Loss of a 7q gene,CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasmsSemantic proximity Read ↗

Regulation of cell proliferation and differentiation in the kidney.Semantic proximity Read ↗

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemiaSemantic proximity Read ↗

Clinically Significant CUX1 Mutations Are Frequently Subclonal and Common in Myeloid Disorders With a High Number of Co-mutated Genes and Dysplastic Features.Semantic proximity Read ↗

Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.Semantic proximity Read ↗

Polycystic kidneys caused by sustained expression of Cux1 isoform p75.Semantic proximity Read ↗

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