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Article

CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.

Nature reviews. Cancer - 1 Oct 2014

Ramdzan Zubaidah M, Nepveu Alain

Abstract excerpt

CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and progression. The accumulated evidence supports a model of haploinsufficiency whereby reduced CUX1 expression promotes tumour development. Paradoxically, increased CUX1 expression is associated with tumour progression, and ectopic CUX1 expression in transgenic mice increases tumour burden in several tissues. One CUX1...

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Source

Identifiers

PMID: 25190083
DOI: 10.1038/nrc3805

Genes

CUX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.PMID 25190083Read ↗

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Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.Semantic proximity Read ↗

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CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemiaSemantic proximity Read ↗

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