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Article

Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.

Oncogene - 1 Mar 2023

An Ningfei, Khan Saira, Imgruet Molly K, Jueng Lia, Gurbuxani Sandeep, McNerney Megan E

Abstract excerpt

-7/del(7q) is prevalent across subtypes of myeloid neoplasms. CUX1, located on 7q22, encodes a homeodomain-containing transcription factor, and, like -7/del(7q), CUX1 inactivating mutations independently carry a poor prognosis. As with loss of 7q, CUX1 mutations often occur early in disease pathogenesis. We reported that CUX1 deficiency causes myelodysplastic syndrome in mice but was insufficient to drive acute...

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Identifiers

PMID: 36725889
DOI: 10.1038/s41388-023-02612-x
PMCID: PMC10068965

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