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Sex‐specific effects of in vitro fertilization on adult metabolic outcomes and hepatic transcriptome and proteome in mouse

18 Mar 2021

Abstract excerpt

Although in vitro fertilization (IVF) is associated with adverse perinatal outcomes, there is increasing concern about the long-term and sex-specific health implications. Augmenting our IVF mouse model to longitudinally investigate metabolic outcomes in offspring from optimal neonatal litter sizes, we found sex-specific metabolic outcomes in IVF offspring. IVF-conceived females had higher body weight and...

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PMID: 33734487
DOI: 10.1096/fj.202002744r

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