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Article

The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences.

Virology - 5 Jan 2014

Atkins Elizabeth, Tatineni Ranjitha, Li Hui, Gretch David, Harris Mark, Griffin Stephen

Abstract excerpt

Secreted infectious particles generated by the genotype 2a JFH-1 hepatitis C virus infectious clone are resistant to acidic pH, whereas intracellular virions remain acid-labile. Thus, JFH-1 particles are thought to undergo pH maturation as they are secreted from the cell. Here, we demonstrate tha...

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Identifiers

PMID: 24314642
DOI: 10.1016/j.virol.2013.10.003
PMCID: PMC7615703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24314642-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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