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Article

Accurate detection of subclonal single nucleotide variants in whole genome amplified and pooled cancer samples using HaloPlex target enrichment.

BMC genomics - 5 Dec 2013

Berglund Eva C, Lindqvist Carl Mårten, Hayat Shahina, Övernäs Elin, Henriksson Niklas, Nordlund Jessica, Wahlberg Per, Forestier Erik, Lönnerholm Gudmar, Syvänen Ann-Christine

Abstract excerpt

BACKGROUND: Target enrichment and resequencing is a widely used approach for identification of cancer genes and genetic variants associated with diseases. Although cost effective compared to whole genome sequencing, analysis of many samples constitutes a significant cost, which could be reduced by pooling samples before capture. Another limitation to the number of cancer samples that can be analyzed is often the...

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PMID: 24314227
DOI: 10.1186/1471-2164-14-856
PMCID: PMC4046713

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