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Article

Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus.

PloS one - 1 Jan 2013

Tsurumura Toshiharu, Qiu Hao, Yoshida Toru, Tsumori Yayoi, Hatakeyama Dai, Kuzuhara Takashi, Tsuge Hideaki

Abstract excerpt

Influenza pandemics with human-to-human transmission of the virus are of great public concern. It is now recognized that a number of factors are necessary for human transmission and virulence, including several key mutations within the PB2 subunit of RNA-dependent RNA polymerase. The structure of the middle domain in PB2 has been revealed with or without m(7)GTP, thus the middle domain is considered to be novel...

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Identifiers

PMID: 24312396
DOI: 10.1371/journal.pone.0082020
PMCID: PMC3843726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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