The Surface-Exposed PA 51-72 -Loop of the Influenza A Virus Polymerase Is Required for Viral Genome Replication

Abstract excerpt

Influenza A viruses are a major global health threat, not only causing significant morbidity and mortality every year but also having the potential to cause severe pandemic outbreaks like the 1918 influenza pandemic. The viral polymerase is a protein complex which is responsible for transcription and replication of the viral genome and therefore is an attractive target for antiviral drug development. For that...

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