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Article

Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

PloS one - 1 Jan 2012

Ng Andy Ka-Leung, Chan Wai-Hon, Choi Sze-Ting, Lam Mandy Ka-Han, Lau Kwok-Fai, Chan Paul Kay-Sheung, Au Shannon Wing-Ngor, Fodor Ervin, Shaw Pang-Chui

Abstract excerpt

The ribonucleoprotein (RNP) complex is the essential transcription-replication machinery of the influenza virus. It is composed of the trimeric polymerase (PA, PB1 and PB2), nucleoprotein (NP) and RNA. Elucidating the molecular mechanisms of RNP assembly is central to our understanding of the control of viral transcription and replication and the dependence of these processes on the host cell. In this report, we...

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Identifiers

PMID: 22570712
DOI: 10.1371/journal.pone.0036415
PMCID: PMC3343083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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