Clinical and Biological Characterization of Bipolar Disorder Patients With Chronic Insomnia Reveals Cortisol Reductions, Elevated TNF-α, and Increased Genetic Risk for Accelerated Aging.

doi:10.1111/bdi.70187

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clinical and Biological Characterization of Bipolar Disorder Patients With Chronic Insomnia Reveals Cortisol Reductions, Elevated TNF-α, and Increased Genetic Risk for Accelerated Aging.

Bipolar disorders - 1 Nov 2026

Rohr Kayla E, Schaffer Charles B, Schaffer Linda C, Nordahl Thomas E, Shih Pei-An, Kelsoe John R, McCarthy Michael J

Abstract excerpt

BACKGROUND: Among patients with bipolar disorder, chronic insomnia is a common comorbidity that adversely affects mood instability, quality of life, disability, accelerated aging, and increased suicide risk. METHODS: This matched case-control study characterized the clinical features of insomnia in a bipolar disorder clinic population and identified biological and genetic correlates affecting diurnal patterns of...

Read the complete abstract on PubMed

Topics

Humans
Female
Tumor Necrosis Factor-alpha
Bipolar Disorder
Hydrocortisone
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sleep Initiation and Maintenance Disorders

Adult

Case-Control Studies

Middle Aged

Cross-Sectional Studies

Aging, Premature

Genetic Predisposition to Disease

Chronic Disease

Source

Open in PubMed

Identifiers

PMID: 42765467
DOI: 10.1111/bdi.70187

Genes

INS
TNF
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and Biological Characterization of Bipolar Disorder Patients With Chronic Insomnia Reveals Cortisol Reductions, Elevated TNF-α, and Increased Genetic Risk for Accelerated Aging.PMID 42765467Read ↗

Advances in the pathophysiology of bipolar disorderSemantic proximity Read ↗

Insomnia and Telomere Length in Older AdultsSemantic proximity Read ↗

Clock gene signature predicts Insomnia and links to sleep/circadian parametersSemantic proximity Read ↗

The relationship between insomnia and complex diseases—insights from genetic dataSemantic proximity Read ↗

Genetic liability to insomnia and substance use disorders in patients with bipolar disorderSemantic proximity Read ↗

Biological and clinical insights from genetics of insomnia symptomsSemantic proximity Read ↗

Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder.Semantic proximity Read ↗

Genome-wide analysis of insomnia disorder.Semantic proximity Read ↗

Insomnia and its impact on physical and mental health.Semantic proximity Read ↗

Exploration of Genetic Liability to Insomnia and Substance Use Disorders in Patients With Bipolar Disorder.Semantic proximity Read ↗

Somatic Morbidity in Bipolar DisordersSemantic proximity Read ↗

Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.