Article
Coeliac disease screening in first-degree relatives on the basis of biopsy and genetic risk.
European journal of gastroenterology & hepatology - 1 Mar 2014
Vaquero Luis, Caminero Alberto, Nuñez Alejandro, Hernando Mercedes, Iglesias Cristina, Casqueiro Javier, Vivas Santiago
Abstract excerpt
BACKGROUND: Serological markers of coeliac disease (CD) lack diagnostic value to identify mild histopathological lesions mainly in adults at risk of CD. AIMS: The aim of this study was to evaluate the usefulness of human leukocyte antigen (HLA)-DQ2/8 genotyping, followed by duodenal biopsy for the detection of CD in adult first-degree relatives (FDRs) of patients with CD. MATERIALS AND METHODS: Ninety-two adult...
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