Article
The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes.
The Journal of biological chemistry - 27 Aug 2004
Marchini Antonio, Marttila Tiina, Winter Anja, Caldeira Sandra, Malanchi Ilaria, Blaschke Rüdiger J, Häcker Beate, Rao Ercole, Karperien Marcel, Wit Jan M, Richter Wiltrud, Tommasino Massimo, Rappold Gudrun A
Abstract excerpt
Mutations in the homeobox gene SHOX cause growth retardation and the skeletal abnormalities associated with Léri-Weill, Langer, and Turner syndromes. Little is known about the mechanism underlying these SHOX-related inherited disorders of bone formation. Here we demonstrate that SHOX expression in osteogenic stable cell lines, primary oral fibroblasts, and primary chondrocytes leads to cell cycle arrest and...
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