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Article

Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2013

Chin Joanna Y, Reza Faisal, Glazer Peter M

Abstract excerpt

Potentiating homologous recombination using triplex-forming peptide nucleic acids (PNAs) can be used to mediate targeted sequence editing by donor DNAs and thereby induce functional gene expression to supplant non-functional counterparts. Mutations that disrupt the normal function of the β-globin...

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Source

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Identifiers

PMID: 23337982
DOI: 10.1038/mt.2012.262
PMCID: PMC3589157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23337982-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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