Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing.

doi:10.1007/s10549-013-2780-y

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Article

Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing.

Breast cancer research and treatment - 1 Jan 2014

Radovich Milan, Clare Susan E, Atale Rutuja, Pardo Ivanesa, Hancock Bradley A, Solzak Jeffrey P, Kassem Nawal, Mathieson Theresa, Storniolo Anna Maria V, Rufenbarger Connie, Lillemoe Heather A, Blosser Rachel J, Choi Mi Ran, Sauder Candice A, Doxey Diane, Henry Jill E, Hilligoss Eric E, Sakarya Onur, Hyland Fiona C, Hickenbotham Matthew, Zhu Jin, Glasscock Jarret, Badve Sunil, Ivan Mircea, Liu Yunlong, Sledge George W, Schneider Bryan P

Abstract excerpt

Triple-negative breast cancers (TNBCs) are a heterogeneous set of tumors defined by an absence of actionable therapeutic targets (ER, PR, and HER-2). Microdissected normal ductal epithelium from healthy volunteers represents a novel comparator to reveal insights into TNBC heterogeneity and to inform drug development. Using RNA-sequencing data from our institution and The Cancer Genome Atlas (TCGA) we compared the...

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PMID: 24292813
DOI: 10.1007/s10549-013-2780-y
PMCID: PMC3901081

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