Article
Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study.
British journal of cancer - 21 Jan 2014
Phelan C M, Iqbal J, Lynch H T, Lubinski J, Gronwald J, Moller P, Ghadirian P, Foulkes W D, Armel S, Eisen A, Neuhausen S L, Senter L, Singer C F, Ainsworth P, Kim-Sing C, Tung N, Llacuachaqui M, Chornokur G, Ping S, Narod S A
Abstract excerpt
BACKGROUND: The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes. METHODS: We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence...
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