Article
Familial colorectal cancer risk may be lower than previously thought: a Danish cohort study.
Cancer epidemiology - 1 Oct 2015
Lautrup Charlotte K, Mikkelsen Ellen M, Lash Timothy L, Katballe Niels, Sunde Lone
Abstract excerpt
BACKGROUND: The risk of colorectal cancer (CRC) is reportedly increased two-fold if at least one first-degree relative (FDR) is affected with CRC, increasing to three- to four-fold if multiple FDRs are affected or if one FDR was diagnosed at a young age. We evaluated familial risk of CRC, systematically excluding monogenetic high-risk families with polyposis or Lynch syndrome/hereditary non-polyposis colorectal...
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