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Article

BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis.

BMC cancer - 29 Aug 2023

Feng Zhewen, Yang Xiaobao, Tian Mingwei, Zeng Na, Bai Zhigang, Deng Wei, Zhao Yanyan, Guo Jianru, Yang Yingchi, Zhang Zhongtao, Yang Yun

Abstract excerpt

BACKGROUND: Breast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers. However, the role of BRCA is unclear in colorectal cancer; the results regarding the association between BRCA gene mutations and colorectal cancer risk are inconsistent and even controversial. This study aimed to investigate whether BRCA1 and BRCA2 gene mutations...

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Identifiers

PMID: 37644384
DOI: 10.1186/s12885-023-11328-w
PMCID: PMC10464413

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