[ALS disease modeling and drug screening using patient-specific iPS cells].

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder in which motor neuron (MN) loss in the spinal cord leads to progressive paralysis and death. Cytosolic aggregations in ALS MNs are composed of Tar DNA-binding protein-43 (TDP-43). Genetic analysis has identified more than twenty mutations of TDP-43 in ALS cases. Although accumulating evidence provides several hypotheses of disease mechanism, it...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Oxidative Stress
• Share to Amyotrophic Lateral Sclerosis
• Share to Drug Discovery