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Article

Matrix metalloproteinase-2 C(-1306)T promoter polymorphism and breast cancer risk in the Saudi population.

Acta biochimica Polonica - 1 Jan 2013

Saeed Hesham Mahmoud, Alanazi Mohammad Saud, Alshahrani Omair, Parine Narasimha Reddy, Alabdulkarim Huda Abdullah, Shalaby Manal Aly

Abstract excerpt

Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the present study, we investigate whether this MMP-2 SNP is associated with susceptibility to breast...

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PMID: 24051440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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