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Article

Defects in base excision repair sensitize cells to manganese in S. cerevisiae.

BioMed research international - 1 Jan 2013

Stephenson Adrienne P, Mazu Tryphon K, Miles Jana S, Freeman Miles D, Reams R Renee, Flores-Rozas Hernan

Abstract excerpt

Manganese (Mn) is essential for normal physiologic functioning; therefore, deficiencies and excess intake of manganese can result in disease. In humans, prolonged exposure to manganese causes neurotoxicity characterized by Parkinson-like symptoms. Mn(2+) has been shown to mediate DNA damage possibly through the generation of reactive oxygen species. In a recent publication, we showed that Mn induced oxidative DNA...

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Identifiers

PMID: 24282812
DOI: 10.1155/2013/295635
PMCID: PMC3825218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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