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Article

Quantitative identification of mutant alleles derived from lung cancer in plasma cell-free DNA via anomaly detection using deep sequencing data.

PloS one - 1 Jan 2013

Kukita Yoji, Uchida Junji, Oba Shigeyuki, Nishino Kazumi, Kumagai Toru, Taniguchi Kazuya, Okuyama Takako, Imamura Fumio, Kato Kikuya

Abstract excerpt

The detection of rare mutants using next generation sequencing has considerable potential for diagnostic applications. Detecting circulating tumor DNA is the foremost application of this approach. The major obstacle to its use is the high read error rate of next-generation sequencers. Rather than increasing the accuracy of final sequences, we detected rare mutations using a semiconductor sequencer and a set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24278442
DOI: 10.1371/journal.pone.0081468
PMCID: PMC3836767

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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