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Article

Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons.

PloS one - 1 Jan 2013

Rushton David J, Mattis Virginia B, Svendsen Clive N, Allen Nicholas D, Kemp Paul J

Abstract excerpt

Optimal use of patient-derived, induced pluripotent stem cells for modeling neuronal diseases is crucially dependent upon the proper physiological maturation of derived neurons. As a strategy to develop defined differentiation protocols that optimize electrophysiological function, we investigated the role of Ca(2+) channel regulation by astrocyte conditioned medium in neuronal maturation, using whole-cell patch...

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Identifiers

PMID: 24278369
DOI: 10.1371/journal.pone.0081031
PMCID: PMC3838360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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